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Published on: February 7, 2017
Synthesis of a library of benzoindolizines using poly(ethylene glycol) as soluble support
Guizhou Yue1, Yadong Wan, Shaojun Song
1Faculty of Chemistry and Material Science, Hubei University, Wuhan, Hubei 430062, China.
Abstract:
A library of benzoindolizines (pyrrolo [1,5-a] quinolines 10 and pyrrolo [1,5-a] quinolines 9) has been synthesized using poly(ethylene glycol) (PEG) as soluble polymer support. The PEG-supported isoquinolinium salt 4 reacted, respectively, with active alkenes 11 using tetrakispyridinecobalt(II) dichromate (TPCD) as oxidant or alkynes 12 to give 10, of which yields were from moderate to high. By analogy, the reaction of PEG-supported quinolinium salt 3 with 12 was to produce 9. However, in the presence of TPCD the reaction of 3 with 11 afforded indolizines 8, which was discovered firstly.

