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Published on: December 22, 2016
[Effect of saikosaponins on epileptic rat electroenciphalogram]
Yun-sheng Huang1, Wei Xie, Bao-tian Chen
1Department of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China. hnhys2002@yahoo.com.cn
Objective:
To study the effect of saikosaponins on the electroencephalogram (EEG) of epileptic rats to evaluate its therapeutic effect against epilepsies.
Methods:
Sixty 8-week-old healthy SD rats were randomized into normal control group (A), epileptic model group (B), lamotrigine group (C), and 3 saikosaponin groups of small, moderate and high doses (D, E, and F groups, respectively), with 10 rats in each group. Penicillin was used to induce epilepsy in the latter 5 groups, and the EEG and onset of epileptic seizures were observed in each group.
Results:
In group B, the EEG contained obvious epileptic discharges, which were not found in that in group A. After treatment with saikosaponins and lamotrignie, the EEG of group C and F became normal, whereas the EEG in group D still contained epileptic discharges at a low level, and that in group E was basically normal. The EEGs of group C, D, E, and F were significantly different from that in group B (P<0.001).
Conclusion:
Saikosaponins can obviously alleviate the severity of epileptic seizure in epileptic rats.
