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Drastically lowering the titer of waterborne bacteriophage PRD1 by exposure to immobilized hydrophobic polycations
Faina Gelman1, Kim Lewis, Alexander M Klibanov
1Department of Chemistry and Division of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Biotechnology Letters
|December 18, 2004
Abstract:
Decrease in the titer of bacteriophage PRD1 (a model of animal adenoviruses) in aqueous solutions caused by the presence of systematically chemically derivatized surfaces was kinetically investigated. The greatest loss of infectivity--up to a 4-log reduction in the titer--was observed with immobilized hydrophobic polyethylenimine-based and dendrimer-based polycations.
