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A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
Is there a link between malignant hyperthermia and exertional heat illness?
Sheila Muldoon1, Patricia Deuster, Barbara Brandom
1Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. smuldoon@usuhs.mil
Abstract:
Exertional heat illness (EHI) and malignant hyperthermia (MH) are two potentially lethal conditions. It has been suggested that a subset of MH susceptible persons may be predisposed to EHI. We examine the current understanding of these disorders and explore evidence of a relationship. Screening for the muscle type I ryanodine receptor gene should help clarify the relationship between MH and EHI.
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