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Genome scan meta-analysis for hypertension.

Wenlei Liu1, Wei Zhao, Gary A Chase

  • 1Department of Health Evaluation Sciences, Penn State College of Medicine, Hershey, Pennsylvania 07033, USA. wliu@hes.hmc.psu.edu

American Journal of Hypertension
|December 21, 2004
PubMed
Summary

This genome scan meta-analysis for hypertension did not find genome-wide significant linkage regions. However, suggestive linkage was observed in several chromosomal areas, indicating complex genetic influences on hypertension.

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Area of Science:

  • Genetics
  • Cardiovascular Disease Research
  • Statistical Genomics

Background:

  • Genome scans for hypertension have produced inconsistent results.
  • Lack of statistical power in individual studies may explain non-replication of linkage findings.
  • A meta-analysis was performed to increase power and refine linkage evidence for hypertension.

Purpose of the Study:

  • To conduct a genome scan meta-analysis for hypertension.
  • To increase statistical power for detecting linkage.
  • To enhance evidence for genetic linkage to hypertension.

Main Methods:

  • Applied a newly developed Genome Search Meta-analysis (GSMA) method.
  • Pooled results from six genome scans reported across five publications.

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Main Results:

  • No chromosomal regions showed genome-wide significant linkage to hypertension.
  • Several regions exhibited suggestive linkage, including 2p, 5q, 6q, 8p, 9p, 9q, and 11q.

Conclusions:

  • No single region appears to have a large, uniform impact on hypertension.
  • Identifying susceptibility genes for hypertension remains challenging.