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Identification of diadenosine-triphosphate in mature bovine lenses
Benjamin S Szwergold1, Sundeep Lal
1Dartmouth Medical School, Hanover, NH, USA. szwergold@dartmouth.edu
Biochemical and Biophysical Research Communications
|December 21, 2004
Abstract:
Mature bovine lenses contain 75-100 microM of a previously unidentified nucleoside polyphosphate. Using (31)P NMR spectroscopy we have identified this compound as diadenosine-5',5'''-triphosphate. The accumulation of this compound in the lens may be a consequence of the high levels of activities of t-RNA synthetases during lens differentiation and growth. The function, if any, of this compound in the bovine lenses is presently unknown.