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Updated: Aug 14, 2026

Measurement of Natural Killer Cell-Mediated Cytotoxicity and Migration in the Context of Hepatic Tumor Cells
Published on: February 22, 2020
Coordination of activating and inhibitory signals in natural killer cells
Sabrina Chiesa1, Elena Tomasello, Eric Vivier
1Centre d'Immunologie de Marseille-Luminy, INSERM-CNRS-Université de la Méditerranée, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France.
Abstract:
NK cells are equipped with multiple activating and inhibitory cell surface receptors whose engagement regulate NK cell effector function (i.e. cytotoxicity as well as chemokine and cytokine production). Several components (adaptors, effector molecules) that participate to NK cell signalling pathways have been described. Yet, the spatio-temporal organisation of these pathways is still poorly understood. In addition, the mechanisms that integrate several simultaneous input signals in NK cells remain to be elucidated.
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