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CandidaDB: a genome database for Candida albicans pathogenomics.

C d'Enfert1, S Goyard, S Rodriguez-Arnaveilhe

  • 1Unité Postulante Biologie et Pathogénicité Fongiques, INRA USC 2019, Institut Pasteur, Paris, France. denfert@pasteur.fr

Nucleic Acids Research
|December 21, 2004
PubMed
Summary

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CandidaDB provides a comprehensive genomic database for Candida albicans, a major human fungal pathogen. This resource aids researchers in analyzing gene function and understanding the C. albicans genome.

Area of Science:

  • Mycology
  • Genomics
  • Bioinformatics

Background:

  • Candida albicans is a prevalent systemic fungal pathogen.
  • Genomic data for C. albicans is crucial for understanding its biology and pathogenicity.
  • Existing resources may lack comprehensive, integrated genomic information.

Purpose of the Study:

  • To develop and present CandidaDB, a dedicated database for the C. albicans genome.
  • To provide researchers with tools for analyzing gene function and exploring genomic data.
  • To facilitate large-scale and specific genomic analyses of C. albicans.

Main Methods:

  • Annotation of C. albicans genome sequence data by the European Galar Fungail Consortium.
  • Utilizing the GenoList relational data schema and WWW interface for eukaryotic genomes.

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  • Implementing tools for browsing, pattern searching, and examining allelic sequences.
  • Main Results:

    • CandidaDB Release 2.0 contains 6244 annotated entries (130 tRNA, 5917 protein-coding genes).
    • Provides tentative functional assignments and pre-run analyses for gene evaluation.
    • Includes tools for navigating individual supercontigs and allelic sequences.

    Conclusions:

    • CandidaDB offers a valuable, integrated resource for C. albicans genomic research.
    • The database facilitates efficient exploration and analysis of the C. albicans genome.
    • Accessible online, CandidaDB supports diverse research needs in fungal pathogen genomics.