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RatMap--rat genome tools and data.

Greta Petersen1, Per Johnson, Lars Andersson

  • 1Department of Cell and Molecular Biology-Genetics, Göteborg University, Box 462, SE 40530 Göteborg, Sweden.

Nucleic Acids Research
|December 21, 2004
PubMed
Summary

RatMap is a comprehensive resource for rat genome data, including genes, markers, and quantitative trait loci (QTLs). It offers tools for QTL analysis and comparative genomics, aiding rat research.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Comparative Genomics

Background:

  • The Rat Genome Database (RatMap) has been a primary resource for rat genomic information since 1994.
  • It is maintained by CMB-Genetics at Goteborg University, Sweden, and focuses on curated rat genes, DNA markers, and quantitative trait loci (QTLs).

Purpose of the Study:

  • To provide an updated overview of the Rat Genome Database (RatMap) and its functionalities.
  • To highlight the database's role in facilitating rat gene nomenclature, QTL identification, and comparative mapping.

Main Methods:

  • Data curation and integration of rat genes, polymorphic DNA markers, and QTLs.
  • Development and provision of bioinformatics tools for QTL analysis and gene characterization.
  • Generation of comparative gene maps between rat, mouse, and human genomes.

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Main Results:

  • RatMap offers a unified presentation of the rat genome sequence and integrated linkage maps.
  • The database includes tools for identifying and characterizing rat QTLs and estimating gene structures.
  • Comparative gene maps are available, facilitating cross-species genomic research.

Conclusions:

  • RatMap serves as an essential, curated resource for the rat research community.
  • The database supports various aspects of rat genomics, from gene nomenclature to comparative analysis.
  • Its integrated data and tools enhance the study of rat genetics and disease models.