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Induction of antigen cross-presentation by Toll-like receptors
1University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0663, USA. sdatta@ucsd.edu
Abstract:
Cross-presentation is the pathway by which exogenous antigens are routed for presentation on MHC class I for activation of CD8(+) T cells. This pathway is important for the development of CD8(+) cytotoxic T lymphocyte responses against tumors and infectious pathogens that do not directly infect APC. We review studies showing that certain Toll-like receptors mediate cross-presentation by dendritic cells, initiating cytosolic processing of antigen after inducing dendritic cell maturation. The implications of these studies for understanding CD8(+) T cell activation and implementing novel vaccine strategies is considered.
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