Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nuclear import in viral infections.

U F Greber1, M Fornerod

  • 1Zoologisches Institut der Universität Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland. ufgreber@zool.unizh.ch

Current Topics in Microbiology and Immunology
|December 22, 2004
PubMed
Summary

Viruses hijack cellular machinery for nuclear import of their genetic material. Understanding these diverse viral strategies offers insights into nucleo-cytoplasmic transport mechanisms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MN1 overexpression is driven by loss of DNMT3B methylation activity in inv(16) pediatric AML.

Oncogene·2017
Same author

C-terminal BRE overexpression in 11q23-rearranged and t(8;16) acute myeloid leukemia is caused by intragenic transcription initiation.

Leukemia·2017
Same author

miR-139-5p controls translation in myeloid leukemia through EIF4G2.

Oncogene·2015
Same author

Adenovirus-triggered innate signalling pathways.

European journal of microbiology & immunology·2014
Same author

miR-9 is a tumor suppressor in pediatric AML with t(8;21).

Leukemia·2013
Same author

A new function of ROD1 in nonsense-mediated mRNA decay.

FEBS letters·2012

Area of Science:

  • Cell Biology
  • Virology
  • Molecular Biology

Background:

  • Cellular processes like transcription and translation are spatially separated, necessitating nucleo-cytoplasmic transport.
  • Viruses exploit the host cell's nucleo-cytoplasmic trafficking pathways for their replication.
  • The nuclear pore complex (NPC) regulates the passage of molecules between the nucleus and cytoplasm.

Purpose of the Study:

  • To review the mechanisms of receptor-mediated nuclear import of proteins.
  • To explore diverse viral strategies for the nuclear import of viral genomes and particles.
  • To highlight the significance of nucleo-cytoplasmic transport for nuclear-replicating viruses.

Main Methods:

  • Review of literature on nuclear import mechanisms.
  • Analysis of viral strategies for nucleo-cytoplasmic transport.
  • Discussion of viral entry into the nucleus.

Main Results:

  • Principal mechanisms of receptor-mediated nuclear import via the NPC are discussed.
  • Viral strategies for nuclear import of genomes and subgenomic particles are diverse.
  • Viruses that replicate in the nucleus utilize various import mechanisms.

Conclusions:

  • Viral strategies for nuclear import are varied and continue to reveal insights.
  • Investigating viral nucleo-cytoplasmic transport enhances understanding of fundamental cellular processes.
  • Nucleo-cytoplasmic transport is crucial for the life cycle of many viruses.

Related Experiment Videos