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Association between primary hyperparathyroidism and increased body weight: a meta-analysis
Mark J Bolland1, Andrew B Grey, Greg D Gamble
1Osteoporosis Research Group, Department of Medicine, University of Auckland, Private Bag 92 019, Auckland 1020, New Zealand. m.bolland@auckland.ac.nz
The Journal of Clinical Endocrinology and Metabolism
|December 23, 2004
Summary
Patients with primary hyperparathyroidism are heavier than those without the condition. This increased body weight may explain links between primary hyperparathyroidism and other health issues.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Public Health
Background:
- Primary hyperparathyroidism is often asymptomatic.
- It is linked to hypertension, insulin resistance, dyslipidemia, cardiovascular mortality, and cancer.
- Previous research indicates patients with primary hyperparathyroidism are heavier than controls.
Purpose of the Study:
- To determine if patients with primary hyperparathyroidism have increased body weight compared to eucalcemic controls.
- To explore the potential contribution of increased body weight to extraskeletal complications of primary hyperparathyroidism.
Main Methods:
- Systematic literature search of MEDLINE (1975-2003) for studies comparing body weight or BMI in primary hyperparathyroidism patients and controls.
- Meta-analysis of data from 17 eligible studies.
- Calculation of standard mean difference for weight and BMI.
Main Results:
- Patients with primary hyperparathyroidism were significantly heavier (3.34 kg) than controls in 13 studies.
- A trend towards increased BMI (1.13 kg/m²) was observed in four studies.
- Overall meta-analysis showed a significant increase in weight/BMI (0.3 SD) in primary hyperparathyroidism patients.
Conclusions:
- Patients with primary hyperparathyroidism are heavier than their eucalcemic counterparts.
- Increased body weight is a potential factor contributing to extraskeletal complications associated with primary hyperparathyroidism.