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Related Experiment Videos

Splenic hamartoma with bizarre stromal cells.

Wah Cheuk1, Arthur K C Lee, Neeru Arora

  • 1Department of Pathology, Queen Elizabeth Hospital, Hong Kong. cheuk_wah@hotmail.com

The American Journal of Surgical Pathology
|December 23, 2004
PubMed
Summary

Splenic hamartomas, rare spleen tumors, can present with unusual bizarre stromal cells. Recognizing this variant is crucial to avoid misdiagnosing it as malignancy.

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Area of Science:

  • Pathology
  • Oncology
  • Gastroenterology

Background:

  • Splenic hamartoma is a rare benign tumor of the spleen.
  • It is characterized by disorganized red pulp tissue without interspersed white pulp.

Observation:

  • This report details three cases of splenic hamartoma with previously unreported scattered bizarre stromal cells.
  • These lesions were solitary, circumscribed, and unencapsulated, featuring vascular channels and a loose stroma.
  • The bizarre stromal cells exhibited atypical nuclear features but lacked mitotic activity.

Findings:

  • The bizarre stromal cells were negative for a wide range of markers including lymphoid, dendritic cell, histiocytic, myeloid, endothelial, epithelial, and melanocytic markers.
  • Rare bizarre cells showed focal desmin positivity in one case.

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  • No evidence of malignancy was found in any of the cases.

    • Implications:

    • The presence of bizarre stromal cells in splenic hamartoma can mimic malignancy.
    • Accurate histopathological identification is essential to prevent misdiagnosis and unnecessary treatment.
    • This finding expands the known morphologic spectrum of splenic hamartoma.