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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

Respiratory syncytial virus activity--United States, 2003-2004

    MMWR. Morbidity and Mortality Weekly Report
    |December 23, 2004
    PubMed

    Insights

    Respiratory syncytial virus (RSV) causes significant hospitalizations in young children and severe illness in vulnerable populations. Monitoring RSV trends is crucial for timely diagnosis and prevention of respiratory infections.

    Area of Science:

    • Virology
    • Epidemiology
    • Public Health

    Background:

    • Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections (LRTIs), including bronchiolitis and pneumonia, in young children.
    • RSV infections lead to substantial annual hospitalizations, estimated between 51,000-82,000.
    • The virus poses a severe risk to older adults and individuals with compromised respiratory, cardiac, or immune systems, and can worsen existing chronic conditions.

    Purpose of the Study:

    • To summarize trends in RSV activity reported to the National Respiratory and Enteric Virus Surveillance System (NREVSS).
    • To present preliminary data on the onset of the 2004-05 RSV season.
    • To inform healthcare providers about RSV diagnosis, prevention, and management.

    Main Methods:

    • Analysis of RSV surveillance data from the National Respiratory and Enteric Virus Surveillance System (NREVSS).
    • Review of trends from July 2003 to June 2004.
    • Examination of preliminary data from July 3 to December 4, 2004, to identify the start of the RSV season.

    Main Results:

    • The report details trends in RSV activity during the 2003-2004 season.
    • Preliminary data indicated the commencement of the 2004-2005 RSV season by early December 2004.
    • RSV seasonality in temperate climates is characterized by annual winter outbreaks.

    Conclusions:

    • Healthcare providers should consider RSV in the differential diagnosis for all individuals presenting with LRTIs.
    • Implementing appropriate isolation precautions is essential to prevent nosocomial transmission of RSV.
    • Eligible children, particularly premature infants and those with chronic lung or heart conditions, should receive appropriate immune prophylaxis.

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