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Updated: Aug 20, 2026

Flypub To Study Ethanol Induced Behavioral Disinhibition and Sensitization
Published on: May 18, 2020
A human PBPK model for ethanol describing inhibition of gastric motility
George D Loizou1, Martin Spendiff
1Health and Safety Laboratory, Broad Lane, Sheffield, S3 7HQ, UK.
Abstract:
A physiologically based pharmacokinetic model for investigating inter-individual and inter-racial variability in ethanol pharmacokinetics is presented. The model is a substantial modification of an existing model which described some genetic polymorphisms in the hepatic alcohol dehydrogenase enzymes. The model was modified to incorporate a description of ethanol absorption from the stomach and gastro-intestinal tract and the retardation of gastric emptying due to a concentration-dependent inhibition of gastric peristalsis. In addition, intra-venous and intra-arterial routes of administration were added to investigate whether the biological structure of the model provided a core which may be easily adapted for any route of exposure. The model is proposed as suitable for the investigation of the effects of both acute and chronic ethanol exposure.
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