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Manganese-enhanced magnetic resonance imaging (MEMRI): methodological and practical considerations
Afonso C Silva1, Jung Hee Lee, Ichio Aoki
1Laboratory of Functional and Molecular Imaging, National Institutes of Neurological Disorders and Stroke, Bethesda, MD 20892-1065, USA. SilvaA@ninds.nih.gov
NMR in Biomedicine
|December 24, 2004
Summary
Manganese-enhanced MRI (MEMRI) offers unique T1 contrast for visualizing brain and heart activity, neuronal connections, and brain structure. This review focuses on safe and effective Mn2+ delivery methods for MEMRI applications.
Area of Science:
- Neuroimaging
- Molecular Imaging
- Biomedical Engineering
Background:
- Manganese-enhanced MRI (MEMRI) utilizes T1 contrast sensitive to biological processes.
- MEMRI applications include visualizing brain/heart activity, tracing neuronal connections, and enhancing brain cytoarchitecture.
- MEMRI is emerging as a key molecular imaging technique for in vivo neural circuit and anatomy visualization.
Purpose of the Study:
- To review practical approaches for Manganese-enhanced MRI (MEMRI).
- To emphasize experimental methodologies for Mn2+ delivery in MEMRI.
- To address the critical need for safe and effective Mn2+ dosing in MEMRI.
Main Methods:
- Review of existing Manganese-enhanced MRI (MEMRI) methodologies.
- Focus on practical aspects of Mn2+ delivery for in vivo imaging.
- Discussion of dose optimization to balance efficacy and toxicity.
Main Results:
- MEMRI demonstrates utility in visualizing brain and heart activity.
- Neuronal connections and brain cytoarchitecture can be traced using MEMRI.
- Successful MEMRI application hinges on efficient and safe Mn2+ delivery.
Conclusions:
- Manganese-enhanced MRI (MEMRI) is a valuable tool for in vivo molecular imaging.
- Optimizing Mn2+ delivery is crucial for MEMRI's successful and safe application.
- Further research into MEMRI methodologies will enhance its utility in neuroscience and cardiology.