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The Mouse Phenome Project.

Molly A Bogue1, Stephen C Grubb

  • 1The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA. mollyb@jax.org

Genetica
|December 29, 2004
PubMed
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The Mouse Phenome Project provides essential baseline phenotypic data for laboratory mice, crucial for understanding genetics and disease. This publicly accessible database aids researchers in selecting mouse strains for diverse biological and medical studies.

Area of Science:

  • Genomics
  • Translational Medicine
  • Comparative Biology

Background:

  • The laboratory mouse is a key model organism in biological and medical research.
  • Accurate phenotypic data are vital for interpreting genomic information from human and mouse genome sequencing projects.

Purpose of the Study:

  • To establish a comprehensive collection of baseline phenotypic data for common and diverse inbred mouse strains.
  • To make this phenotypic data publicly accessible via a web-based database.
  • To provide tools for exploring raw data and performing comparative analyses.

Main Methods:

  • Systematic collection of phenotypic data across various inbred mouse strains.
  • Development of the Mouse Phenome Database (MPD) for data management.
  • Inclusion of detailed protocols and raw data within the MPD.

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Main Results:

  • Creation of a publicly accessible repository of baseline phenotypic data for mouse strains.
  • Development of a database (MPD) enabling data exploration and comparative analysis.
  • Provision of resources to aid strain selection for diverse research applications.

Conclusions:

  • The Mouse Phenome Database is a valuable resource for the scientific community.
  • Facilitates research in areas such as physiological testing, drug discovery, toxicology, and disease modeling.
  • Supports genetic research, including QTL analysis and gene identification, by integrating genotype and phenotype data.