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Updated: Aug 20, 2026
An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur
Published on: October 23, 2017
[The effect of platelet-rich plasma on the distraction osteogenesis]
Quan-feng Luo1, Xing Wang, Xiao-xia Wang
1Department of Oral and Maxillofacial Surgery, Peking University School of Stomatology, Beijing 100081, China. lqf6668@163.com
Objective:
To observe the effect of the platelet-rich plasma (PRP) on osteogenesis during bone distraction.
Methods:
The osteoblasts were cultured in vitro. The rabbits were used as the animal model of distraction osteogenesis. The proliferation of osteoblasts was analysed through MTT methods. The osteogenesis was observed by histochemical and histoimmunochemical methods.
Results:
PRP stimulated the proliferation of osteoblasts and facilitated distraction osteogenesis.
Conclusions:
PRP could accelerate the osteogenesis during bone distraction. The application of PRP in clinical practice might shorten the period of distraction osteogenesis.
