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Pathbase: a new reference resource and database for laboratory mouse pathology.

Paul N Schofield1, Jonathan B L Bard, Jacques Boniver

  • 1Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK. PS@mole.bio.cam.ac.uk

Radiation Protection Dosimetry
|December 30, 2004
PubMed
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This summary is machine-generated.

Pathbase provides a web-accessible database of mouse histopathology images for researchers. This resource aids in coding and archiving data from genetically engineered mouse models, improving experimental biology research.

Area of Science:

  • * Histopathology
  • * Bioinformatics
  • * Mouse Models

Background:

  • * Pathbase is a web-accessible database.
  • * It archives histopathological images of laboratory mice.
  • * It is a resource for analyzing mutant or genetically engineered mice.

Purpose of the Study:

  • * To create a centralized repository for mouse histopathology images.
  • * To facilitate data retrieval and interoperability with other databases.
  • * To provide a formal description of mouse histopathological image content using the MPATH vocabulary.

Main Methods:

  • * Development of a web-accessible database.
  • * Utilization of orthogonal ontologies and controlled vocabularies for metadata.
  • * Implementation of the MPATH (Mouse Pathology) controlled vocabulary.

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Main Results:

  • * Over 1000 histopathological images are currently online.
  • * An additional 2000 images are under curation.
  • * The database supports data coding and archiving for mouse models.

Conclusions:

  • * Pathbase serves as a valuable resource for researchers studying mouse histopathology.
  • * The database design presents a paradigm for future experimental biology databases.
  • * Standardized vocabularies like MPATH enhance data interoperability and analysis.