Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The second valve system in lymphatics.

Geert W Schmid-Schönbein1

  • 1Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California, San Diego, La Jolla, California 92093-0412, USA. gwss@bioeng.ucsd.edu

Lymphatic Research and Biology
|December 31, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction to "Pancreatic Digestive Enzyme Dispersion into Human Organs Outside the Gastrointestinal Tract".

Journal of proteome research·2026
Same author

Pancreatic Digestive Enzyme Dispersion into Human Organs Outside the Gastrointestinal Tract.

Journal of proteome research·2025
Same author

Arterial compliance is improved via enteral serine protease inhibition in experimental trauma/hemorrhagic shock.

Frontiers in physiology·2025
Same author

Aging by autodigestion.

PloS one·2024
Same author

Anti-Obesity Effect of Rice Bran Extract on High-Fat Diet-Induced Obese Mice.

Preventive nutrition and food science·2022
Same author

Digestive Enzyme Activity and Protein Degradation in Plasma of Heart Failure Patients.

Cellular and molecular bioengineering·2021
Same journal

Prevalence and Predictors of Cancer-Related Fatigue in Breast Cancer-Related Lymphedema Patients: A Cross-Sectional Study.

Lymphatic research and biology·2026
Same journal

The Effect of a Series of Lower Limb Pressotherapy Treatments on the Range of Motion of the Lower Limb Joints, Lower Limb Circumferences, and Body Composition in Young, Healthy Women.

Lymphatic research and biology·2026
Same journal

<sup>23</sup>Na-MRI Measures Tissue Sodium in Human Leg Lymphedema.

Lymphatic research and biology·2026
Same journal

Inflammatory Markers in Lipedema: A Comparative Analysis of Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Mean Platelet Volume.

Lymphatic research and biology·2026
Same journal

Neuropathic Pain Features in Lipedema Compared to Lymphedema: An Exploratory Cross-Sectional Study.

Lymphatic research and biology·2026
Same journal

Lipedema: Exploring Relationship Between Physical and Psychological Symptoms in Affected Patients-A Mixed-Methods Study.

Lymphatic research and biology·2026
See all related articles

Researchers propose a novel two-valve system in initial lymphatics to explain unidirectional interstitial fluid flow. This mechanism, involving endothelial and intralymphatic valves, clarifies microcirculation fluid dynamics.

Area of Science:

  • Physiology
  • Microcirculation
  • Lymphatic System

Background:

  • Interstitial fluid uptake into lymphatic vessels is poorly understood.
  • Existing intralymphatic valves are insufficient for unidirectional flow in initial lymphatics.
  • The precise mechanism driving lymphatic fluid transport remains speculative.

Purpose of the Study:

  • To propose a novel two-valve system for unidirectional flow in initial lymphatics.
  • To elucidate the mechanism of interstitial fluid uptake in the microcirculation.
  • To address the limitations of current understanding of lymphatic valve function.

Main Methods:

  • Conceptual model development based on existing literature.
  • Analysis of lymphatic valve structure and function.

Related Experiment Videos

  • Hypothesizing the role of endothelial and intralymphatic valves.

    • Main Results:

    • A two-valve system is proposed for initial lymphatics.
    • Primary (endothelial) and secondary (intralymphatic) valves work in concert.
    • This system facilitates unidirectional flow during lymphatic vessel compression and expansion.

    Conclusions:

    • The proposed two-valve system provides a plausible mechanism for lymphatic fluid uptake.
    • This model enhances understanding of microcirculation and fluid homeostasis.
    • Further research is needed to experimentally validate the endothelial valve system.