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Updated: Aug 20, 2026

Using Solution NMR to Characterize Biomolecular Condensates Under Biphasic Conditions
Published on: April 17, 2026
Diffusion NMR spectroscopy in supramolecular and combinatorial chemistry: an old parameter--new insights
Yoram Cohen1, Liat Avram, Limor Frish
1School of Chemistry, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel. ycohen@post.tau.ac.il
Abstract:
Intermolecular interactions in solution play an important role in molecular recognition, which lies at the heart of supramolecular and combinatorial chemistry. Diffusion NMR spectroscopy gives information over such interactions and has become the method of choice for simultaneously measuring diffusion coefficients of multicomponent systems. The diffusion coefficient reflects the effective size and shape of a molecular species. Applications of this technique include the estimation of association constants and mapping the intermolecular interactions in multicomponent systems as well as investigating aggregation, ion pairing, encapsulation, and the size and structure of labile systems. Diffusion NMR spectroscopy can also be used to virtually separate mixtures and screen for specific ligands of different receptors, and may assist in finding lead compounds.
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