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Updated: Aug 20, 2026

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
[Cellular immunity in childhood iron deficiency anemia with recurrent respiratory infections]
Objective:
To examine interleukin-2 (IL-2) activity,serum soluble IL-2 receptor (sIL-2R) level and T lymphocyte subsets in peripheral blood from 63 childhood iron deficiency anemia (IDA) patients with recurrent respiratory infections(RRI).
Methods:
IL-2 activity, sIL-2R level and T lymphocyte subsets were assayed by MTT, ELISA and APAAP, respectively.
Results:
IL-2 activity, percentages of CD3+ and CD4+ cells as well as the ratio of CD4+/ CD8+ cells in the patients were significantly lower ( P < 0.01),while sIL-2R levels were higher than that in normal controls (P < 0.01). No significant change was found in the percentage of CD8+ cells.
Conclusion:
Cellular immunity was impaired in childhood IDA with RRI.
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