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Updated: Aug 20, 2026

Postsynaptic Recordings at Afferent Dendrites Contacting Cochlear Inner Hair Cells: Monitoring Multivesicular Release at a Ribbon Synapse
Published on: February 10, 2011
Structure and function of ribbon synapses
Peter Sterling1, Gary Matthews
1Department of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA. peter@retina.anatomy.upenn.edu
Abstract:
Sensory neurons with short conduction distances can use nonregenerative, graded potentials to modulate transmitter release continuously. This mechanism can transmit information at much higher rates than spiking. Graded signaling requires a synapse to sustain high rates of exocytosis for relatively long periods, and this capacity is the special virtue of ribbon synapses. Vesicles tethered to the ribbon provide a pool for sustained release that is typically fivefold greater than the docked pool available for fast release. The current article, which is part of the TINS Synaptic Connectivity series, reviews recent evidence for this fundamental computational strategy and its underlying cell biology.
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