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Control of cyclooxygenase-2 transcriptional activation by pro-inflammatory mediators

K K Wu1

  • 1Vascular Biology Research Center and Division of Hematology, Department of Internal Medicine, Institute of Molecular Medicine and Medical School, University of Texas Health Science Center at Houston, TX 77030, USA. kenneth.k.wu@uth.tmc.edu

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The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
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RNA Polymerase II Accessory Proteins

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Master Transcription Regulators

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