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Related Experiment Videos

Primitive neuroectodermal tumor of the stomach.

Raoulin Soulard1, Valère Claude, Philippe Camparo

  • 1Laboratoire d'Anatomie Pathologique, Hôpital d'Instruction des Armées du Val-de Grâce, Paris, France. cellule_suspecte@yahoo.fr <cellule_suspecte@yahoo.fr>

Archives of Pathology & Laboratory Medicine
|January 5, 2005
PubMed
Summary

This study reports the first known case of primitive neuroectodermal tumor originating in the stomach. This rare visceral tumor was successfully surgically removed from a 66-year-old woman.

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Area of Science:

  • Oncology
  • Pathology
  • Genetics

Background:

  • Ewing sarcoma/primitive neuroectodermal tumor (PNET) typically affects bone and soft tissues in younger individuals.
  • Recent findings indicate that PNET can also arise from visceral organs, expanding its known clinicopathologic spectrum.
  • The visceral origin of PNET is an area of growing research interest.

Observation:

  • A case of PNET was identified in the stomach of a 66-year-old female patient.
  • The tumor presented as solid nests and sheets of round cells microscopically.
  • Immunohistochemical analysis revealed CD99, S100, neuron-specific enolase, and vimentin expression.

Findings:

  • The gastric PNET exhibited characteristic immunoreactivity for CD99, S100, neuron-specific enolase, and vimentin.

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  • Genetic analysis confirmed the presence of an EWS-ERG fusion, a hallmark of Ewing sarcoma family tumors.
  • The neoplasm was completely excised via a radical surgical procedure.

    • Implications:

    • This case represents the first documented instance of a primitive neuroectodermal tumor arising in the stomach.
    • The findings contribute to the understanding of rare PNET presentations and their visceral origins.
    • Highlights the importance of considering PNET in the differential diagnosis of gastric tumors, particularly in older adults.