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Updated: Jul 26, 2026

Rapid Generation of Amyloid from Native Proteins In vitro
05:48

Rapid Generation of Amyloid from Native Proteins In vitro

Published on: December 5, 2013

Molecular basis for amyloid fibril formation and stability

O Sumner Makin1, Edward Atkins, Pawel Sikorski

  • 1Structural Medicine, Department of Haematology, University of Cambridge, Cambridge Institute for Medical Research, Hills Road, Cambridge CB2 2XY, United Kingdom.

Proceedings of the National Academy of Sciences of the United States of America
|January 5, 2005
PubMed
Summary

Researchers determined the detailed molecular structure of amyloid fibrils using sequence-designed polypeptides. This breakthrough reveals antiparallel beta-sheet arrangements and stabilizing interactions within amyloid fibers.

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