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Updated: Aug 20, 2026
Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
[Relationship between heparanase mRNA expression in human gastric cancer and its clinicopathological features]
Jun-qiang Chen1, Wen-hua Zhan, Yu-long He
1Department of Gastrointestinopancreatic Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Objective:
To explore the relationship between heparanase mRNA expression and clinicopathological parameters in human gastric cancer.
Methods:
RT-PCR was used to detect the expression of heparanase mRNA in 43 human gastric carcinomas and 10 adjacent normal gastric tissues.
Results:
Heparanase mRNA was expressed in 29 of the 43 cases of gastric cancer with a positive rate of 67.4%, which was significantly higher than that in adjacent normal gastric tissues (P = 0.013). The expression level was higher in late-stage tumors (stage III and IV) than in early-stage tumors (stage I and II) (P = 0.001), in tumors with invasion to serosa than those without serosal invasion (P = 0.009), in tumors with lymph node metastasis than those without lymph node metastasis (P = 0.018), and in large-sized tumors than in small-sized ones (P = 0.009). The expression was not correlated with patients' age, sex, tumor location, histologic types, differentiation, peritoneal dissemination and liver metastasis (P > 0.05).
Conclusion:
Heparanase might play an important role in the development of invasion and metastasis of gastric cancer.
