Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Developmental changes in parvalbumin regulate presynaptic Ca2+ signaling.

Thibault Collin1, Mireille Chat, Marie Gabrielle Lucas

  • 1Laboratory of Cerebral Physiology, Centre National de la Recherche Scientifique, University Paris 5, 75006 Paris, France.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|January 7, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Time-dependent plasma metabolic shifts and mechanistic insights into systemic consequences of cerebral ischemia in middle-aged patients.

Metabolomics : Official journal of the Metabolomic Society·2026
Same author

ATR and TopBP1 oppose to control dormant origin activity and global replication dynamics, providing a first defense against replication stress.

Nucleic acids research·2026
Same author

Disrupted SR-Mitochondria Coupling Drives Ischemia-Reperfusion Vulnerability in the Middle-Aged Rat Heart.

Biomedicines·2026
Same author

Ultrafast carrier dynamics and electronic properties of PtSe<sub>2</sub>/MoSe<sub>2</sub> and WSe<sub>2</sub> 2D TMDC layered structures on mica: combined THz spectroscopy and DFT study.

RSC advances·2026
Same author

Intracellular Calcium Changes Correlate with Mitochondrial Dynamics After Differential Modulation of KATP Channels in a Cellular Model of Parkinson's Disease.

Neurochemical research·2025
Same author

Dzyaloshinskii-Moriya Interaction in Fe<sub>5</sub>GeTe<sub>2</sub> Epitaxial Thin Films.

Nano letters·2025

Parvalbumin (PV) in cerebellar interneurons shapes calcium signaling, accelerating initial decay and adding a slow phase. This impacts synaptic facilitation and delayed transmitter release, crucial for cerebellar circuit function.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Biochemistry

Background:

  • Interneurons utilize calcium-binding proteins (CBPs) like parvalbumin (PV) for signaling.
  • The precise role of PV in presynaptic calcium dynamics and synaptic transmission remains unclear.

Purpose of the Study:

  • To investigate the cell-specific and developmental impact of PV on presynaptic calcium dynamics in cerebellar interneurons.
  • To elucidate the functional consequences of PV on synaptic transmission at interneuron-interneuron synapses.

Main Methods:

  • Whole-cell recording and fluorescence imaging of action potential-evoked calcium transients in mouse cerebellar interneuron axons.
  • Biochemical and immunocytochemical analyses of PV expression.
  • Comparative studies using wild-type and PV-deficient mice.

Related Experiment Videos

  • Numerical simulations of calcium dynamics.

    • Main Results:

    • PV expression is cell-specific and developmentally regulated in cerebellar interneurons.
    • PV accelerates the initial decay of presynaptic calcium signals and introduces a slow decay phase during bursts.
    • PV-dependent delayed neurotransmitter release occurs at interneuron-interneuron synapses following bursts of action potentials.
    • PV concentration in axons is estimated at approximately 150 µM.

    Conclusions:

    • Parvalbumin is a key regulator of presynaptic calcium dynamics in cerebellar interneurons.
    • PV influences synaptic facilitation and mediates delayed transmitter release, impacting synaptic integration in the cerebellar cortex.