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Related Experiment Videos

Right ventricular diastolic function in chronic obstructive lung disease.

S Marangoni1, S Scalvini, M Schena

  • 1Dept of Cardiopulmonary Rehabilitation, Fondazione Clinica del Lavoro di Pavia, Gussago, Italy.

The European Respiratory Journal
|April 1, 1992
PubMed
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Early detection of right ventricular diastolic dysfunction in chronic obstructive lung disease (COLD) patients is crucial. Pulsed Doppler echocardiography effectively assesses this dysfunction, correlating well with pulmonary artery pressure.

Area of Science:

  • Cardiology
  • Pulmonology
  • Medical Imaging

Background:

  • Early detection of diastolic dysfunction in chronic obstructive lung disease (COLD) patients holds significant prognostic value.
  • Echocardiography is established for assessing left ventricular diastolic function, but noninvasive methods for right ventricular diastolic function are lacking.
  • Right ventricular diastolic dysfunction is a key concern in COLD patients, particularly those with pulmonary hypertension.

Purpose of the Study:

  • To evaluate the utility of pulsed Doppler echocardiography in assessing right ventricular diastolic function in COLD patients.
  • To compare right ventricular diastolic function parameters between COLD patients with and without pulmonary hypertension, and healthy controls.
  • To determine the correlation between echocardiographic diastolic parameters and mean pulmonary artery pressure in COLD patients.

Related Experiment Videos

Main Methods:

  • Pulsed Doppler echocardiography was employed to assess right ventricular diastolic function.
  • Three groups were studied: COLD patients with pulmonary hypertension (n=35), COLD patients without pulmonary hypertension (n=32), and control subjects (n=18).
  • Key parameters measured included A/E ratio, deceleration half times (DHT), and isovolumic relaxation times (Pc-To).

Main Results:

  • Significant differences in A/E ratio, DHT, and Pc-To were observed in COLD patients with pulmonary hypertension compared to the other two groups.
  • The A/E ratio demonstrated 82% sensitivity and 90% specificity, while Pc-To showed 77% sensitivity and 72% specificity.
  • A strong correlation (multiple correlation coefficient = 0.75) was found between diastolic parameters (A/E, ACT, DHT, Pc-To) and mean pulmonary artery pressure in both hypertensive and normotensive COLD patients.

Conclusions:

  • 2D echo-Doppler is a valuable tool for evaluating right ventricular diastolic function in COLD patients, especially those with pulmonary hypertension.
  • The study highlights the significant differences in diastolic parameters in hypertensive COLD patients.
  • Echocardiographic diastolic parameters show a high correlation with mean pulmonary artery pressure in COLD patients, regardless of pulmonary hypertension status.