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Continuous longitudinal regression equations for pulmonary function measures.

D L Sherrill¹, M D Lebowitz, R J Knudson

¹Division of Respiratory Sciences (Westend Research Laboratories), University of Arizona, College of Medicine, Tucson 85724.

The European Respiratory Journal

|April 1, 1992

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Maximal expiratory flow-volume (MEFV) measures show rapid development in youth, followed by a plateau and then decline in adulthood. Lung function changes differ between sexes and flow measures versus volume measures.

Area of Science:

Pulmonary Physiology
Longitudinal Aging Studies
Biostatistics

Background:

Understanding lung function changes over the lifespan is crucial for identifying normal aging patterns and potential disease markers.
Previous studies often relied on cross-sectional data, limiting insights into individual lung function trajectories.
Longitudinal data allows for a more accurate description of developmental and decline phases in respiratory health.

Purpose of the Study:

To describe the age-related development and decline of maximal expiratory flow-volume (MEFV) measures using longitudinal data.
To compare these trajectories between sexes and with existing cross-sectional findings.
To identify specific age intervals for distinct phases of lung function change.

Main Methods:

Related Experiment Videos

Analysis of data from 930 healthy, nonsmoking adults in the Tucson Longitudinal Population Study (1972-1988).

Utilized statistical methods for continuous piecewise linear regression with repeated, unequally spaced measures.

Estimated age intervals for linear segments of MEFV indices, comparing results between sexes.

Main Results:

All MEFV measures exhibit accelerated development during the adolescent growth spurt.
A plateau phase of approximately 10 years for FEV1 and FVC in males is followed by a consistent decline.
Flow measures lacked a distinct plateau but showed later-life increases in decline rates, differing from volume measures.

Conclusions:

Lung function (MEFV measures) follows distinct developmental, plateau, and decline phases influenced by age and sex.
Longitudinal analysis reveals nuanced patterns in lung function changes, particularly the absence of a plateau in flow measures.
Findings provide a detailed, age-specific reference for healthy lung function development and decline over the adult lifespan.