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Development of an in vitro model system for studying the interaction of Equus caballus IgE with its high-affinity receptor FcεRI
Published on: November 1, 2014
Equine anhidrosis
Jeremy D Hubert1, Ralph E Beadle, Gary Norwood
1School of Veterinary Medicine, Department of Veterinary Clinical Sciences, Equine Health Studies Program, Louisiana State University, Baton Rouge, LA 70803, USA. jhubert@mail.vetmed.lsu.edu
Abstract:
The molecular basis of the pathophysiology of anhidrosis is still not well understood. Therefore, treatments are more often based on clinical impressions than on scientific fact. Treatment options for this condition will improve only when more is known about the molecular events that cause anhidrosis, especially as they relate to beta2-receptor dysfunction and stimulus-secretion coupling in the sweat glands of affected horses. Although this additional information is being attained, sound environmental management will continue to be a very important aspect of the treatment of horses affected with anhidrosis.
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