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[Meningococcal disease in western Galilee]
Abstract:
79 patients with meningococcal disease were evaluated retrospectively between 1972-1986. All the neisseria isolated were sensitive to penicillin but resistant to sulphonamides. Most of the infections (54%) were caused by serogroup B strains. Clinical features included fever (98%), vomiting (65%), and headache (60%). Purpura appeared in 95% and severe neurological features in 25%. Most patients (83%) were children less than 10 years old. The incidence was 1.4/100,000 in the non-Jewish population and 2.3/100,000 in the Jewish population. The overall mortality was 23%, but about 50% in the Jewish population (10 deaths in 18 cases). In kibbutzim the incidence (7.5/100,000) and mortality were especially high. The need for awareness of the disease and the importance of early diagnosis and aggressive treatment are emphasized.
Insights
Meningococcal disease outbreaks between 1972-1986 were primarily caused by serogroup B strains, showing resistance to sulphonamides. Early diagnosis and treatment are crucial for reducing high mortality rates, especially in vulnerable populations.
Area of Science:
- Infectious Diseases
- Epidemiology
- Microbiology
Context:
- Retrospective analysis of 79 meningococcal disease cases from 1972-1986.
- Isolated Neisseria strains were penicillin-sensitive but sulphonamide-resistant.
- Serogroup B strains predominated, accounting for 54% of infections.
Purpose:
- To evaluate the clinical features, epidemiology, and outcomes of meningococcal disease.
- To identify risk factors and demographic patterns associated with the disease.
- To highlight the importance of timely medical intervention.
Summary:
- Fever, vomiting, headache, and purpura were common clinical manifestations.
- The disease predominantly affected children under 10 years old.
- Higher incidence and mortality were observed in the Jewish population and in kibbutzim.
Impact:
- The study underscores the need for heightened awareness and prompt diagnosis of meningococcal disease.
- Aggressive treatment strategies are essential to mitigate severe outcomes and mortality.
- Findings provide insights into historical disease patterns and inform public health strategies.