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Choriocarcinoma following a partial hydatidiform mole: a case report
1Department of Pathology, Beth Israel Hospital, Boston, MA 02215.
Human Pathology
|April 1, 1992
Summary
Choriocarcinoma, a rare cancer, can develop after a partial hydatidiform mole. This case highlights the importance of monitoring for persistent gestational trophoblastic disease, even after initial treatment.
Area of Science:
- Gynecologic Oncology
- Reproductive Endocrinology
- Pathology
Background:
- Hydatidiform moles are classified histologically as partial or complete.
- Persistent gestational trophoblastic tumors can follow both types of moles.
- The potential for choriocarcinoma to arise from a partial hydatidiform mole remains a subject of debate.
Observation:
- A 37-year-old woman with a partial hydatidiform mole experienced persistent disease requiring chemotherapy.
- Following a 10-month remission, a rise in serum beta-human chorionic gonadotropin indicated recurrence.
- Histologic examination revealed choriocarcinoma with marked atypia.
Findings:
- Flow cytometry demonstrated the partial hydatidiform mole was triploid.
- The subsequent choriocarcinoma was found to be diploid.
- The patient had no evidence of metastatic disease at diagnosis.
Implications:
- This case provides evidence that choriocarcinoma can arise from a partial hydatidiform mole.
- It underscores the necessity for vigilant follow-up of patients with gestational trophoblastic disease.
- Successful treatment was achieved with multi-agent chemotherapy.
