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Sesquiterpenes, lignans and other constituents from Saussurea macrota
Min Yang1, Chun-Ming Wang, Qi Zhang
1College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, People's Republic of China.
Abstract:
From the methanol extract of the whole plant of Saussurea macrota Franch, 21 compounds were isolated. Their structures were elucidated by spectroscopic methods and X-ray crystallography. Two of them are new: 3alpha-hydroxy-11alphaH-guaia-4(15),10(14)-diene-12,6alpha-olide (1) and 7'-hydroxyiso-lappaol A (11). Compound 2 is reported as a natural compound for the first time. In addition, the compounds 12 and 13 showed significant antitumor activity against Bel-7402 and HO-8910 cells. Some of the compounds exhibited weak antibacterial activity against Staphylococcus aureus, Bacillus subtilis and Escherichia coli.
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