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Updated: Aug 20, 2026
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Morphometrical analysis of immunohistochemical reaction of inflammatory infiltrate in chronic thyroiditis
E Nieruchalska1, E Kaczmarek, D Jarmołowska-Jurczyszyn
1Laboratory of Morphometry and Medical Image Processing, University of Medical Sciences, Poznań, Poland.
Abstract:
The aim of the study was to quantitatively evaluate B and T lymphocytes and macrophages, based on immunohistochemical investigations (CD43, CD20, CD8 and CD68) of chronic focal and Hashimoto thyroiditis. A new method of image analysis was applied, based on spatial visualization of the antigens reactivity. The obtained results indicated that the numbers of lymphocytes, in particular of cytotoxic T lymphocytes, and of macrophages increased with the progress of inflammatory process. Quantitative measurements of the markers made the results more objective and supported pathomorphological diagnosis.
