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Binding of alpha1-antichymotrypsin to the surface of lymphocytes--preliminary study
1Department of Physiotherapy, Rheumatology and Rehabilitation, Karol Marcinkowski University of Medical Sciences, Poznań, Poland. magdula2811@poczta.onet.pl
Purpose:
The paper presents preliminary results of investigation of binding of alpha1-antichymotrypsin to the surface of peripheral blood lymphocytes.
Material And Methods:
Pooled serum samples from healthy individuals served as source of alpha1-antichymotrypsin for isolation using chromatography. Binding of alpha1-antichymotrypsin to the surface of peripheral blood lymphocytes was measured by flow cytometry.
Results:
Even on native cells alpha1-antichymotrypsin may be detected. After incubation with isolated preparation the percentage of positive lymphocytes increased.
Conclusions:
The presence of alpha1-antichymotrypsin on the surface of lymphocytes may imply its regulatory role during acute phase response and early immune response.
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