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Related Experiment Videos

Quantifying symptoms in men with interstitial cystitis/prostatitis, and its correlation with potassium-sensitivity

C Lowell Parsons1, Matt T Rosenberg, Pejvak Sassani

  • 1Division of Surgery/Urology, University of California-San Diego Medical Center, 200 West Arbor Drive, San Diego, CA 92103-8897, USA. mseva@ucsd.edu

BJU International
|January 11, 2005
PubMed
Summary

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Men with prostatitis often have bladder pathology, indicated by high scores on the pelvic pain and urgency/frequency (PUF) questionnaire and positive potassium-sensitivity tests (PST). This suggests a continuum of lower urinary tract dysfunction.

Area of Science:

  • Urology
  • Nephrology
  • Gastroenterology

Background:

  • Prostatitis is a common condition in men presenting with lower urinary tract symptoms.
  • The origin of these symptoms is often unclear, with potential involvement of the bladder or prostate.

Purpose of the Study:

  • To investigate the presence of bladder pathology in men diagnosed with prostatitis.
  • To explore the relationship between prostatitis symptoms and bladder dysfunction using validated questionnaires and tests.

Main Methods:

  • The study involved 50 patients with prostatitis and 14 healthy controls.
  • Participants completed the pelvic pain and urgency/frequency (PUF) questionnaire and underwent the potassium-sensitivity test (PST).
  • A separate urethral irrigation study assessed responses to potassium chloride (KCl) and sodium chloride (NaCl) after mucosal injury.

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Main Results:

  • All prostatitis patients scored >= 7 on the PUF questionnaire, and 77% had a positive PST.
  • Controls had low PUF scores (0-1) and negative PST results.
  • Urethral irrigation with KCl, but not NaCl, induced pain after mucosal injury in controls.

Conclusions:

  • A high rate of positive PST in prostatitis patients suggests significant bladder pathology.
  • Symptoms in prostatitis and interstitial cystitis may stem from a shared continuum of epithelial dysfunction and potassium cycling.
  • Lower urinary tract symptoms may represent a spectrum of disease rather than distinct entities.