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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
The neuroendocrine-immune interactions in systemic lupus erythematosus: a basis for understanding disease
Martine Szyper-Kravitz1, Gisele Zandman-Goddard, Robert G Lahita
1Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer 52621, Israel.
Abstract:
Much progress has been made in the understanding of the impact of the neuroendocrine immune interactions and the pathogenic role in systemic lupus erythematosus, clinically and at the molecular level. This article focuses on the intertwining networks that involve the hypothalamic-pituitary-adrenal axis, cytokines within the central nervous system, and the sympathetic system. Hormones (estrogen, prolactin, gonadotropin-releasing hormone, and leptin) play an important role as immunomodulatory agents.
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