[Cloning of novel pituitary growth hormone gene from Rhinopithecus roxellanae]

Putative pituitary growth hormone gene of Rhinopithecus roxellanae was cloned and sequenced. All exons sequences and deduced amino acid sequence (containing 26 residues signal peptide and 191 residues mature protein) were obtained. We constructed a phylogenetic tree,which well reflected the true evolutionary relationship of pituitary growth hormone genes from 7 primates species. From the results of amino acids sequence comparison and analysis of functionally important sites of growth hormone, pituitary growth hormone of macaque from Cercopithecidae and snub-nosed golden monkey from Colobidae show little difference. We indicated that pituitary growth hormone from Cercopithecoidea species have no apparently functional difference.