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Microarray-based resequencing of multiple Bacillus anthracis isolates.

Michael E Zwick1, Farrell Mcafee, David J Cutler

  • 1Biological Defense Research Directorate, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA. mzwick@genetics.emory.edu

Genome Biology
|January 12, 2005
PubMed
Summary
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This study generated high-quality genomic sequence data from Bacillus anthracis strains using resequencing arrays. This rapid technology is crucial for identifying new or engineered microbial pathogen strains.

Area of Science:

  • Microbial genomics
  • Population genetics
  • Bioinformatics

Background:

  • Bacillus anthracis poses a significant biosecurity threat.
  • Understanding genetic diversity is key to tracking strains.
  • Rapid genomic analysis is needed for pathogen surveillance.

Purpose of the Study:

  • To assess the utility of custom resequencing arrays for Bacillus anthracis.
  • To generate high-quality genomic data for population studies.
  • To evaluate the speed and accuracy of resequencing arrays for pathogen identification.

Main Methods:

  • Utilized custom-designed resequencing arrays.
  • Generated 3.1 Mb of genomic sequence data.
  • Analyzed a panel of 56 Bacillus anthracis strains.

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Main Results:

  • Achieved high sequence quality with a low discrepancy rate (7.4 x 10(-7)) by replication.
  • Confirmed high accuracy by comparison to independently generated shotgun sequence (< 2.5 x 10(-6)).
  • Demonstrated the feasibility of rapid genomic data generation.

Conclusions:

  • Custom resequencing arrays provide a high-quality, rapid method for microbial pathogen genomics.
  • This technology is critical for identifying emerging or engineered Bacillus anthracis strains.
  • Population genomics studies benefit significantly from rapid resequencing technologies.