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Updated: Jun 30, 2026

Method for Efficient Refolding and Purification of Chemoreceptor Ligand Binding Domain
Published on: December 12, 2017
Dendrimeric gadolinium chelate with fast water exchange and high relaxivity at high magnetic field strength
Valérie C Pierre1, Mauro Botta, Kenneth N Raymond
1Department of Chemistry, University of California-Berkeley, Berkeley, California 94720-1460, USA.
Abstract:
The synthesis and relaxivity properties of a new dendrimeric Gd chelate, Gd-TREN-bisHOPO-TAM-Asp-Asp2-12OH, are presented. The macromolecule demonstrates improved water solubility due to its 12 terminal hydroxyl groups and improved relaxivity due to its optimal water exchange rate and slower molecular tumbling. Unprecedented high relaxivity (r1p = 18 mM-1 s-1) is observed at high magnetic field (90 MHz), an important advance in the development of contrast agents for the next generation of MRI scanners.
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