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View from beneath: pathology in focus. Renal cell carcinoma metastasis to the tongue

Y Okabe1, H Ohoka, T Miwa

  • 1Department of Otolaryngology, Kanazawa University, School of Medicine, Japan.

The Journal of Laryngology and Otology
|March 1, 1992
PubMed

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
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The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...