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Related Experiment Videos

Embryonic loss in iatrogenic multiples.

Richard P Dickey1

  • 1Fertility Institute of New Orleans, 6020 Bullard Avenue, New Orleans, LA 70128, USA. info@fertilityinstitute.com

Obstetrics and Gynecology Clinics of North America
|January 13, 2005
PubMed
Summary

Spontaneous reduction of multiple pregnancies is less common with assisted reproductive technology (ART). ART pregnancies often start as triplets or more, and reduction can impact surviving fetuses.

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Area of Science:

  • Reproductive Medicine
  • Obstetrics
  • Perinatology

Background:

  • Multiple pregnancies are less common with assisted reproductive technology (ART) compared to spontaneous conception.
  • ART-conceived pregnancies have a higher incidence of triplet and higher-order multiples.
  • Spontaneous reduction of gestational sacs (vanishing twins/multiples) occurs in multiple pregnancies.

Purpose of the Study:

  • To compare the rate of spontaneous reduction in multiple pregnancies conceived via ART versus spontaneous conception.
  • To investigate the implications of spontaneous reduction on the outcomes of surviving fetuses in ART pregnancies.

Main Methods:

  • Review of recent evidence on multiple gestations from ART and spontaneous conception.
  • Analysis of ultrasound findings and pregnancy outcomes.
  • Comparison of spontaneous reduction rates between conception groups.

Main Results:

  • Spontaneous reduction of multiple gestational sacs is less frequent in ART pregnancies.
  • ART pregnancies are more likely to be higher-order multiples (triplets or more).
  • Spontaneous reduction, even in ART pregnancies, can have significant consequences for the surviving fetus(es).

Conclusions:

  • The rate of spontaneous reduction differs between ART and spontaneously conceived multiple pregnancies.
  • Higher-order multiple gestations are more prevalent in ART.
  • Further research is needed to understand the consequences of spontaneous reduction on surviving fetuses in ART pregnancies.

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