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Related Experiment Videos

Spatial working memory capacity in unilateral neglect.

Paresh Malhotra1, H Rolf Jäger, Andrew Parton

  • 1Division of Neuroscience, Imperial College, Charing Cross Hospital Campus, London W6 8RF, UK.

Brain : a Journal of Neurology
|January 13, 2005
PubMed
Summary
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Spatial working memory (SWM) deficits contribute to unilateral neglect in stroke patients. New methods show neglect patients have impaired SWM, linked to right parietal and insula damage, worsening visual search tasks.

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Neurology

Background:

  • Unilateral neglect, a common deficit after right hemisphere stroke, may be exacerbated by impaired spatial working memory (SWM).
  • Traditional SWM tasks may not accurately measure capacity in neglect due to confounds like leftward encoding failure or visuomotor deficits.

Purpose of the Study:

  • To develop and validate novel procedures for measuring SWM capacity in patients with unilateral neglect.
  • To investigate the relationship between SWM deficits and the severity of neglect.
  • To identify potential neural correlates of SWM impairment in neglect.

Main Methods:

  • Two computerized vertical SWM tasks were administered to right hemisphere stroke patients (with and without neglect) and controls.
  • Experiment 1 used a vertical Corsi task requiring sequence recall via touchscreen.

Related Experiment Videos

  • Experiment 2 employed a purer SWM measure, probing visual recall of sequence elements without motor response or order dependency.

    • Main Results:

    • Patients with neglect were impaired on both SWM tasks compared to controls.
    • The second, purer SWM task showed significant impairment in the neglect group with minimal overlap with controls.
    • Impaired SWM capacity correlated with neglect severity on cancellation tasks and was associated with damage to right parietal white matter and insula.

    Conclusions:

    • Impairments in spatial working memory capacity are a significant factor contributing to the unilateral neglect syndrome.
    • Novel SWM assessment methods can accurately measure deficits in neglect patients.
    • Damage to right parietal white matter and insula underlies SWM deficits contributing to neglect.