Related Experiment Video
Updated: Aug 20, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
Effect of asthma intervention on children with undiagnosed asthma
Christine L M Joseph1, Suzanne Havstad, Elizabeth W Anderson
1Henry Ford Health System, Department of Biostatistics and Research Epidemiology, Detroit, MI 48202, USA. cjosephl@hfhs.org
Insights
An asthma intervention improved functional status and reduced morbidity in children with undiagnosed asthma, similar to those with diagnosed asthma.
Area of Science:
- Pediatric Pulmonology
- Asthma Management
- Public Health
Background:
- Undiagnosed asthma presents a challenge in pediatric healthcare.
- Assessing functional status and morbidity is crucial for effective asthma management.
- Previous studies have focused primarily on diagnosed asthma populations.
Purpose of the Study:
- To evaluate the impact of a targeted asthma intervention on the functional status and morbidity of children with undiagnosed asthma.
- To compare outcomes between children with undiagnosed asthma receiving an intervention versus a control group.
- To assess if the intervention benefits are comparable to those observed in children with diagnosed asthma.
Main Methods:
- Utilized data from a randomized controlled trial.
- Compared baseline and follow-up outcomes for 299 children with undiagnosed asthma and 510 with diagnosed asthma.
- Stratified analysis for moderate-to-severe cases to assess functional status indicators like symptom-days and restricted activity days.
Main Results:
- Children with undiagnosed asthma reported fewer allergies and respiratory diagnoses compared to diagnosed cases.
- The intervention group with undiagnosed asthma showed significant reductions in symptom-days, symptom-nights, and restricted activity days.
- Similar improvements in functional status were observed for children with diagnosed asthma in the intervention group.
Conclusions:
- An asthma intervention effectively improved functional status and reduced morbidity in children with undiagnosed asthma.
- The intervention's benefits were comparable to those seen in children with diagnosed asthma.
- Findings support the integration of such interventions into strategies for early asthma case detection and management.
Objective:
To measure the effect of an asthma intervention on the functional status and morbidity of children with undiagnosed asthma.
Study Design:
Data from a randomized trial were used to compare outcomes at baseline and follow-up for children with undiagnosed and diagnosed asthma. We studied 510 symptomatic children with diagnosed asthma (diagnosed) and 299 children with symptoms but no diagnosis (undiagnosed). Baseline functioning and morbidity were similar for undiagnosed and diagnosed patients classified as moderate-severe.
Results:
There were fewer undiagnosed reported allergies, seasonal symptoms, and other respiratory diagnoses (all P < 0.01). Among the moderate-severe, functional status, for example, symptom-days ( P = .02), symptom-nights ( P < .01), and days of restricted activity ( P < .01), was significantly reduced at follow-up for the undiagnosed in the intervention group but not for undiagnosed control subjects. Findings were similar for children with diagnosed asthma.
Conclusions:
Children with undiagnosed asthma were generally nonatopic, although some had symptoms at a level comparable to children with a diagnosis. The intervention successfully improved functional status for children with undiagnosed asthma as well as for children with diagnosed asthma. These results can be applied to ongoing discussions related to case detection.
Related Concept Videos
Asthma-IV: Diagnostic and Management
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Asthma-I: Introduction
Asthma I: Introduction
Asthma-IV: Nursing Management
First, in...
Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-III: Symptoms and Complications
Classification of Asthma