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Updated: May 2, 2026
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Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
Published on: June 28, 2021
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[On PACAP-aggravated experimental acute pancreatitis]
Youdai Chen1, Zongguang Zhou, Youqin Chen
1West China Hospital, Sichuan University, Chengdu 610041, China.
Summary
Pituitary adenylate cyclase activating polypeptide (PACAP) promotes inflammation in acute pancreatitis, worsening cerulein-induced pancreatitis. PACAP
Area of Science:
- Endocrinology and Metabolism
- Gastroenterology
- Pathology
Context:
- The role of pituitary adenylate cyclase activating polypeptide (PACAP) in acute pancreatitis pathogenesis remains unclear.
- PACAP is a widely distributed vasoactive and neurotransmissive peptide involved in various physiological processes.
- Experimental models are crucial for elucidating the specific mechanisms of PACAP in pancreatic injury.
Purpose:
- To investigate the effects of exogenous PACAP on normal rat pancreas.
- To determine PACAP's influence on the course of experimental acute pancreatitis induced by cerulein and sodium taurocholate.
- To assess PACAP's impact on pancreatic edema, serum amylase levels, and pancreatic functional capillary density (FCD).
Summary:
- PACAP administration induced pancreatic edema, inflammation, and necrosis in normal rats.
- PACAP exacerbated cerulein-induced pancreatitis, leading to more severe edema, elevated amylase, ascites, bleeding, and necrosis.
- PACAP showed mixed effects in sodium taurocholate-induced pancreatitis, attenuating edema and amylase but causing hemorrhage and necrosis.
Impact:
- PACAP acts as a proinflammatory agent in acute pancreatitis.
- PACAP, particularly in combination with cerulein, can induce severe hemorrhagic and necrotizing pancreatitis.
- PACAP's specific actions may differ depending on the pancreatitis induction method, highlighting complex regulatory roles.
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