Related Experiment Video
Updated: Aug 20, 2026

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries
Published on: December 27, 2016
Antibacterial activity from Penicillium corylophilum Dierckx
Marley Garcia Silva1, Niege Araçari Jacometti Cardoso Furtado, Mônica Tallarico Pupo
1Faculdade de Filosofia, Ciências e Letras de Formiga, Fundação Educacional Comunitária Formiguense, Avenida Dr Arnaldo de Senna, 328 CEP 35570 000 Formiga MG, Brazil.
Abstract:
A strain of Penicillium corylophilum isolated from Brazilian soil sample was submitted to different culture conditions to investigate the production of secondary metabolites with antimicrobial activity. The largest number of conidia was obtained after 5 days of incubation in oat medium and the highest level of antimicrobial activity was produced when the fungus culture was developed in the Czapek medium. The activity against Staphylococcus aureus was found only in the chloroform extract from Czapek culture broth, which also showed activity against Micrococcus luteus. Fumiquinozoline F was isolated from the active chloroform extract by using chromatographic methods. The minimal inhibitory concentration (MIC) values for M. luteus and S. aureus were 99 microg/ mL and 137microg/mL, respectively.
Related Concept Videos
Production of Antibiotics
Antimicrobial Effectiveness
Bacterial Phylum Actinobacteria
Inhibitors of Gram-positive Cell Wall Synthesis
Antifungal Agents

