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Fibronectin as a component of pseudophakic acellular membranes
W Boyd1, R L Peiffer, G Siegal
1Department of Ophthalmology, School of Medicine, University of North Carolina 27599-7040.
Journal of Cataract and Refractive Surgery
|March 1, 1992
Summary
Fibronectin was found in membranes and cells surrounding intraocular lenses (IOLs) after implantation. This study investigated fibronectin
Area of Science:
- Ophthalmology
- Cell Biology
- Biochemistry
Background:
- Intraocular lenses (IOLs) are used to restore vision after cataract surgery.
- The formation of pseudophakic membranes can occur after IOL implantation.
- Fibronectin is an extracellular matrix protein involved in cell adhesion and tissue repair.
Purpose of the Study:
- To investigate the presence and localization of fibronectin in pseudophakic membranes and surrounding tissues.
- To understand the role of fibronectin in the biological response to intraocular lens implantation.
Main Methods:
- Avidin-biotin immunohistochemical staining was employed.
- The study analyzed 17 aphakic intraocular lens implanted globes.
- 12 explanted intraocular lenses were also examined.
Main Results:
- Fibronectin was identified as a component of acellular pseudophakic membranes.
- Fibronectin was also observed within lens epithelial cells.
- Macrophages were found to contain fibronectin.
Conclusions:
- Fibronectin is present in the membranes and cells associated with intraocular lenses.
- These findings suggest fibronectin plays a role in the tissue response to IOLs.