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Allergic reactions to isosulfan blue in sentinel lymph node mapping
Ian K Komenaka1, Valerie P Bauer, Freya R Schnabel
1Section of Breast Surgery, Columbia-Presbyterian Medical Center, Columbia University, New York, New York 10032, USA. Komenaka@hotmail.com
The Breast Journal
|January 14, 2005
Summary
Sentinel lymph node (SLN) biopsy dye reactions are rare but require vigilance. Isosulfan blue caused "blue hives" in 0.9% of patients, who recovered with standard treatment.
Area of Science:
- Oncology
- Surgical Pathology
- Dermatology
Background:
- Sentinel lymph node (SLN) biopsy is crucial for staging melanoma and early breast cancer.
- Increasing use of SLN biopsy necessitates understanding dye-related adverse reactions.
Purpose of the Study:
- To assess the incidence and characteristics of allergic reactions to isosulfan blue dye during SLN biopsy.
Main Methods:
- Retrospective review of patients undergoing SLN mapping from June 2000 to July 2002.
- Documentation and examination of records for patients experiencing allergic reactions.
Main Results:
- Three out of 351 patients (0.9%) developed allergic reactions (blue hives) to isosulfan blue.
- Allergic reactions were treated successfully with corticosteroids and diphenhydramine, with recovery within 24 hours.
Conclusions:
- Adverse reactions to SLN biopsy dyes, though uncommon, may increase with technique utilization.
- Maintaining a high index of suspicion and prompt clinical management are essential to minimize morbidity.