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Updated: Aug 9, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Evidence-based decision making: global evidence, local decisions
Carolyn M Clancy1, Kelly Cronin
1Agency for Healthcare Research and Quality (AHRQ), Rockville, Maryland, USA. cclancy@ahrq.gov
Abstract:
Variations in health care services have been well documented worldwide. The result is that increased health care spending is not uniformly associated with improved health. Interest in increasing the value obtained from health care investments has stimulated efforts to develop the best science and apply it to health care delivery. Advances in communications and information technology have made such developments of the scientific basis for health care a truly global enterprise, but its application must remain local. Consumers' use of evidence-based information to choose providers, make treatment decisions, and play a more active role represents the ultimate local application of scientific information.
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